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  1. General Info
  2. Effects Info
  3. Reference
Drug Interaction Details
01. General Information
Pair Name Paeonol, Methotrexate
Phytochemical Name Paeonol (PubChem CID: 11092 )
Anticancer drug Name Methotrexate (PubChem CID: 126941 )
Structure of
Phytochemical		 2D-img
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2D MOL 3D MOL
Structure of
Anticancer Drug		 2D-img
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2D MOL 3D MOL
02. Combinatorial Therapeutic Effect(s)
Synergistic Effect
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Decreasing Drug Toxicity
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The theory of cold and heat
Drug Name Methotrexate
Adverse Reactions Acne, stomatitis, mouth and lip ulcers. This was inferred hot nature anticancer drug.
Recommendations Cold: Paeonia suffruticosa; Scutellaria baicalensis; Centella asiatica; Lonicera japonica
Reference ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.　　ref_link
Combination Pair ID: 444
Ref_1
Pair Name Paeonol, Methotrexate
Disease Info [ICD-11: 2B90] Colon cancer Investigative
Biological Phenomena Induction-->Apoptosis
Gene Regulation Up-regulation Expression ABCB1 hsa5243
Down-regulation Expression CASP3 hsa836
Down-regulation Expression IL1B hsa3553
Down-regulation Expression NFKB1 hsa4790
Down-regulation Expression TLR4 hsa7099
In Vitro Model HCT 116 Colon carcinoma Homo sapiens (Human) CVCL_0291
In Vivo Model Male Wistar rats weighing 180–220 g were used in study.
Result Paeonol protects against MTX-induced nephrotoxicity through antioxidant, anti-inflammatory, and antiapoptotic mechanisms and might potentiate MTX chemotherapeutic efficacy.
03. Reference
No. Title Href
1 Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway. Front Pharmacol. 2022 Feb 4;13:774387. doi: 10.3389/fphar.2022.774387. Click
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